Utilization of Multi Component Reactions in the Synthesis of 1,6- Naphthyridine Derivatives with Expected Biological Activity

Faculty Science Year: 2024
Type of Publication: ZU Hosted Pages: Vol. 67, pp. 151 - 156 (2024)
Authors:
Amira Atef Mahmoud Ghoneim
Journal: Egyptian Journal of Chemistry National Information and Documentation Center (NIDOC) Volume:
Keywords : Utilization , Multi Component Reactions , , Synthesis , 1,6- Naphthyridine    
Abstract:
We have achieved the diastereo selective synthesis of pyrano and furano naphthyridine derivatives through the utilization of Camphor sulfonic acid (CSA) as a catalyst in an ABB' type multi component coupling reaction involving 4-aminopyridine and cyclic enol ethers to form of pyrano and furano naphthyridine in high yields, primarily exhibiting cis diastereo selectivity. Notably, the addition of water as a reagent causes a shift in diastereoselectivity towards the trans isomer. Synthesized compounds were evaluated in vitro for their antimicrobial activities and molecular docking studies were performed.
    
     
 
       

Author Related Publications

  • Amira Atef Mahmoud Ghoneim, "Synthesis and Antimicrobial Activities of New N-Glycoside from Phenyl Pyrazole Derivatives", Horizon Research Publishing, 2014 More
  • Amira Atef Mahmoud Ghoneim, "Synthesis and Antimicrobial Activities of New N-Glycoside from Phenyl Pyrazole Derivatives", Horizon Research Publishing, 2014 More
  • Amira Atef Mahmoud Ghoneim, "Synthesis and Characterization of Antimicrobial Activity of Azoles and Azines", Organic Chem Curr Res, 2015 More
  • Amira Atef Mahmoud Ghoneim, "Synthesis of Some New Hydroquinoline and Pyrimido[4,5-b] Quinoline Derivatives", Current Research in Chemistry, 2015 More
  • Amira Atef Mahmoud Ghoneim, "Synthesis of some nucleosides derivatives from L- rhamnose with expected biological activity", chemistry central journal, 2011 More

Department Related Publications

  • Amr Lotfy Saber Hefny, "Selective Potentiometric Method for Determination of Nitrile in Water Samples Using New PVC Membrane Sensors", International Journal of ELECTROCHEMICAL SCIENCE, 2017 More
  • Ahmed Diab Abdelghafar Khater, "Controlling the passive oxide film formation on indium electrode in Na2B4O7 solutions", science publishing group, 2014 More
  • Salah Abdalwanes AbdulHameed, "Factors affecting the corrosion behaviour of aluminium in acid solutions. II. Inorganic additives as corrosion inhibitors for Al in HCl solutions", corrosion Science, 2013 More
  • Mohamed Gamal Helmy Mohamed Abdelwahed, "Synthesis, Spectral, Antimicrobial, and Thermal Properties of Ce(III), Gd(III), Nd(III), Tb(III), and Er(III) Gliclazide Complexes1", , Russian Journal of General Chemistry, 2016 More
  • Mohamed Yousry Elsayed ebrahim, "Synthesis, Spectral, Antimicrobial, and Thermal Properties of Ce(III), Gd(III), Nd(III), Tb(III), and Er(III) Gliclazide Complexes1", , Russian Journal of General Chemistry, 2016 More
Tweet