Utilization of Multi Component Reactions in the Synthesis of 1,6- Naphthyridine Derivatives with Expected Biological Activity

Faculty Science Year: 2024
Type of Publication: ZU Hosted Pages: Vol. 67, pp. 151 - 156 (2024)
Authors:
Amira Atef Mahmoud Ghoneim
Journal: Egyptian Journal of Chemistry National Information and Documentation Center (NIDOC) Volume:
Keywords : Utilization , Multi Component Reactions , , Synthesis , 1,6- Naphthyridine    
Abstract:
We have achieved the diastereo selective synthesis of pyrano and furano naphthyridine derivatives through the utilization of Camphor sulfonic acid (CSA) as a catalyst in an ABB' type multi component coupling reaction involving 4-aminopyridine and cyclic enol ethers to form of pyrano and furano naphthyridine in high yields, primarily exhibiting cis diastereo selectivity. Notably, the addition of water as a reagent causes a shift in diastereoselectivity towards the trans isomer. Synthesized compounds were evaluated in vitro for their antimicrobial activities and molecular docking studies were performed.
    
     
 
       

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