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Antimicrobial and immunomodulating activities of hesperidin and ellagic acid against diarrheic Aeromonas hydrophila in a murine model
Faculty
Veterinary Medicine
Year:
2013
Type of Publication:
Article
Pages:
714-722
Authors:
Abuelsaad, Abdelaziz S. A, Mohamed, Imad, Allam, Gamal, Al-Solumani, Adnan A
DOI:
10.1016/j.lfs.2013.09.019
Journal:
LIFE SCIENCES PERGAMON-ELSEVIER SCIENCE LTD
Volume:
93
Research Area:
Research \& Experimental Medicine; Pharmacology \& Pharmacy
ISSN
ISI:000326433400002
Keywords :
Antimicrobial, Immunomodulating, Aeromonas, Hesperidin, Ellagic acid, Humoral response
Abstract:
Aims: The present study is designed to evaluate the in vitro and in vivo bactericidal and immunomodulating activities of hesperidin (HES) and ellagic acid (EA) against Aeromonas hydrophila. A hydrophila, an uncommon human pathogen, can cause invasive infections in immunocompromised individuals and common clinical presentations in acute gastrointestinal illness, soft-tissue infections and sepsis. The antimicrobial activities of medicinal plants against A. hydrophila have received only cursory attention. Methods: We examined the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values in vitro. Moreover, the effects of HES and EA against bacterial colonization were studied in vivo. Also, humoral immune response was tested against A. hydrophila-LPS or A. hydrophila-ECP antigen preparations and the intestinal histopathological alterations were studied. Results: Data revealed that the treatments with HES and EA each had antimicrobial activities against A. hydrophila. Both HES and EA treatments significantly increased anti-LPS IgM levels and reduced anti-LPS and anti-ECP IgA levels to their normal values in comparison to the infected group, which recorded significantly elevated levels two week post-infection. In conclusion, the present data suggest that HES and EA have antimicrobial and immunomodulating activities against murine A. hydrophila infections. Significant: These data warrant clinical studies to delineate HES and EA roles in human infectious diseases. (C) 2013 Elsevier Inc. All rights reserved.
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