Despite the positive impact of nanomaterials on agriculture and crop productivity, this effect is not always positive. A pot experiment was under-taken to spot the effect of nanosized ZnO on the physiological and biochemical attributes of Jew’s mallow (Corchorus olitorius L.) by foliar spray applied at three concentrations (25, 50, and 100 mg L-1) in addition to the control. All concentrations, especially 100 mg L-1 of ZnO significantly increased (p≤0.05) plant growth parameters, compared to the control. Protein, carbohydrates and fibers were increased after the application of ZnO NPs by 47, 77 and 94% respectively while fat was not changed. Likewise, significant variations in element contents (N, P, K, Zn and Fe) occurred following the nanosized ZnO application. Moreover, nanosized ZnO induced the activity of catalase and ascorbate peroxidase enzymes and the highest levels were (0.82 and 3.14 U g-1 FW min-1 respectively) recorded at 100 mg L-1of ZnO whereas, causing inhibition in H2O2 and lipid peroxidation content by (9.3 and 31.6 % respectively). Hence, nanosized ZnO can improve plant growth and the nutritive value of Jew’s mallow and can induce tolerance of the plant against oxidative stress.