Poor growth and health disorders are commonly reported issues in ovine in captivity mainly because of gastrointestinal infections and endoparasites. The present study was conducted on 15 nonwormed Ovine kept in diagnosed with Trichuris trichiura (round worm). Infected were selected and randomly divided into 3 groups i.e. A, B and C. Group A and B were treated with mebendazole (20mg/ kg, PO) and levamisole (10 mg/kg, PO), respectively. Group C was designated as the control group. Direct smear technique and simple fecal floatation technique were performed to diagnose positive samples. Pre and post treatment fecal screening were performed on days 0, 7, 14, 21and 28. The effect of both anthelmintic on EPG values was calculated by pre and post treatment fecal screening. Egg per gram (EPG) was determined by using the McMaster technique. EPG values were used to determine the fecal egg count reduction (FECR). Statistically there was a significant decrease in EPG values from day 0-14. On day 28 EPG values were significantly lower than day 0. There was a significant statistical difference between treated and control groups P < 0.05, but there was no statistical significant difference between mebendazole group and levamisole treated groups (P > 0.05). On the basis of numerical difference of mean EPG values and comparison between mebendazole and levamisole group; mebendazole was found to be less effective than levamisole in ovine against Trichuris species. Repeated treatment was suggested for complete clearance of worm infestation in both treated groups.Key words: Olive baboon, levamisole, mebendazole, Trichuris trichura.