Allergen immunotherapy (AIT) commonly used for treatment pruritic skin disease which called canine atopic dermatitis. AIT required mainly for treatment enivermontal allergens has been approves improvement in dogs . new approaches of treatments using immunotherapy of allergenic extracts from regional aerobiology which had been tested intradermal as well as immunoserum has been explained.The goal of this study was to estimate influence monoclonal antibodies in pruritic skin disease of canine. We have old clinic data about dogs suffering from local skin diseases thatstarted using monoclonal immunotherapy fromAug, 2012 to March, 2015. Variationpruritus severity follow up treatment at least 230 days with different degree of influencesfrom excellent to poor was recognized depending on their effects.Out Of the 252 dogs that began starts medication immunoserumall period of study,93 same range of criteria.degree of effectiveness tomedication categorized with grade level from poor 18%,fair 25%, good 38% and excellent 59% of dogs. The effectiveness compared with itching severity and skin lesion (e = 0.52) e = 0.64, p < 0.001), but in same canine statement correlation effect . opposite effect in cases of skin lesion 6/252 (2.3%) of dogs received medication. We summarized and concluded that under normal performance research medication of immunotherapy the environment should be safe and provided every supplies provided in these study to all dogs received immunotherapy properly and efficiently