Nervous signs in canine usually caused by toxoplasma and or viral infection but rarely exempt cases caused by sarcocystis. Adult male cat admitted to clinic with history of nervous signs with highly aggressive, biting himself, shaking head, lethargy. This cat were diagnosed by taking spinal fluid showing merozoites of Sarcocystis and also serum samples positive Elisa titer for sarcocyst and negative for toxoplasma, with necropsy inflammatory central nervous system with neutrophilic pleocytosis. This considered first case of nervous signs in feline associated with sarcocystis. Cryptococcosis and Toxoplasmosis highly common in feline with different stages of clinical signs associated with nervous symptoms or no and cat considered main host for toxoplasma widespread infection everywhere and considered common zoonotic disease