Equine has an important role all over the world of veterinary sciences as well as civilians interesting, but internal parasites affect equine reduce their physical powers and beautiful appearance which is important for racing and showing. We focus in our review on epidemiology diagnosis and treatment of strongylosis as an important parasitic disease in equine. There are two strongyle families; firstly, is the large strongyle which caused stronglus vulgaris which is the most pathogenic and wide spread species in equine that may cause severe internal organs damage. Verminous Arthritis Embolism may cause death due to migration larvae. The second member is the Small strongyle which causes mild symptoms of diarrhea and weight loss. However recent method of diagnosis is the real-time PCR, with advanced molecular biology techniques usage like Cyathastomine Gut Larva Antige(CyGALA-1) for molecular antigen detection that help in early diagnosis which consider one of the best methods of strongylosis eradication and treatment. Current use of Anthelmintic cause wide spread of parasitic diseases with common antigen resistance, so all new goals are set for developing a vaccine that is able to control and eradicate in the safest way possible.