Background: Millions of women's lives are impacted by Nabothian cysts, a significant public health concern that causes psychological suffering in addition to limits on social, physical, and sexual activities. Aim of this research: The aim of this research was to identify risk factors and to evaluate the quality of life for the Egyptian multiparous women presented with cervical Nabothian cysts. Research setting: This research was conducted at outpatient gynecological clinic of Zagazig University Hospitals in Egypt. Research design: A descriptive design was utilized. Research sampling: A purposive sample of 128 women who diagnosed with a Nabothian cyst between January 2023 and January 2024 was selected. Tools of data collection: Consisted of three tools; Tool I: A structured interviewing questionnaire was used. Tool II: Clinical assessment of cervical Nabothian cysts was done. Tool III: Global Quality of Life Scale (GQOL) was used. Results: The results of the present research showed that the development of Nabothian cysts was associated with uterine prolapse, vaginal delivery, cervicitis, and infection. Nabothian cysts had a significant impact on quality of life. Nabothian cysts with diameter greater than 1 cm had bad effect on quality of life. Upper cervical Nabothian cysts had a detrimental effect on quality of life. Furthermore, a high number of Nabothian cysts had a detrimental effect on quality of life. Conclusions: Nabothian cyst formation is thought to be influenced by cervicitis and vaginal births. Enormous, higher cervical Nabothian cysts severely reduced the affected women's quality of life. Recommendation: Raising the awareness of the women about Nabothian cysts causes, manifestations and effect on the quality of life of women is crucial duty of gynecology nurse.