Abstract Background & Aim: Elderly patients with liver cirrhosis may experience a progressive deterioration in liver function due to poor prognosis of their disease. As a consequence, the majority of liver cirrhotic patients report having several symptoms or problems, which might cause which can significantly lower their health related quality of life. Therefore, this study aimed to evaluate the effect of educational program on health related quality of life among elderly patients with liver cirrhosis. Methods & Materials: The quasi-experimental study was conducted in liver diseases center in El-Ahrar Teaching Hospital at Zagazig City.The study sample composed of 80 elderly patients with liver cirhosis, purposively assigned according to study inclusion criteria. Twelve sessions for small groups (2 to 4 elderly patients in each group) were held as part of the program's implementation in the current study. Two tools were used; interview questionnaire which is composed of two parts: Demographic characteristics and Health profile of the studied elderly patients& Chronic Liver Diseases Questionnaire to assess health related quality of life among elderly patients with liver cirrhosis. Results: The study findings reported that total mean score of the studied elderly patients related to CLDQ was 66.90±7.5 pre-program, and then improved to be 144.5±18.4 post program. Also, the current study result reveals that, there were several factors influence health related quality of life related to CLDQ total mean score as chronic disease, duration of diseases, age and complications related to liver cirrhosis. Conclusion: The applied educational program was effective in improving health related quality of life among studied elderly patients with liver cirrhosis.