CYCLOCONDENSATION OF 4-BENZYL-1-HYDRAZINOPHTHALAZINE

1-Hydrazino-4-benzylphthalazine 1 underwent closure and/or condensation reaction with formic acid, acetic acid, acetic anhydride, trifluoroacetic anhydride, ortho esteres, aldehydes, urea or carbon disulphide to afford the N-formyl 3a, N-acyl 3b, and the appropriate 3-substituted-6-benzyl-s-triazolo {[}3,4-a] phthalazines 4a, c, 7, 8. Alkylation of the obtained s-triazolo{[}3,4-a]phthalazine-3-thione 7 and s-triazolo {[}3,4-a]phthalazin-3-one 8 with N-substituted chloroacetamides gave the thioether 9 and N-substitution products 10, respectively. Likewise, applying Mannich conditions of the previously mentioned intermediates 7 and 8 yielded the N-Mannich bases (11 and 12). The The new products were characterized by their elemental and spectral data.