Humans frequently contract the diarrheal disease known as cryptosporidiosis, which is brought on by the protozoan parasite Cryptosporidium. The current study looked at how pomegranate (Punica granatum) peel extracts, garlic (Allium sativum), and ginger (Zingiber officinale) affected the biochemical and antioxidant parameters of a mouse model of experimental cryptosporidiosis. 82 mice were allocated into 6 groups; Control group, Infected non-treated group (experimentally infected by 104 C. oocysts/mouse), Ginger, garlic, and pomegranate groups experimentally infected with C. parvum and treated with the plants’ extracts, as compared to the reference drug, metronidazole (MTZ).We observed that all therapies promoted liver function by reducing serum levels of the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzymes and raising levels of total protein, albumin, and globulin. Furthermore, the levels of serum malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and total antioxidant capacity (TAC) were likewise restored to nearly their normal values in the treated groups. Garlic extract was noticed to have a noteworthy impact on the infected mice than the other treatments and ameliorated health benefits, performing a natural efficient therapeutic alternative, without drug resistance and with the fewest side effects possible for treating cryptosporidiosis