Predictors of Reduced Bone Mineral Density in Juvenile Systemic Lupus Erythematosus.

Faculty Medicine Year: 2023
Type of Publication: ZU Hosted Pages:
Authors:
Journal: geget ESPNT Volume:
Keywords : Predictors , Reduced Bone Mineral Density , Juvenile    
Abstract:
Introduction: One of the juvenile Systemic Lupus Erythematosus (j-SLE) consequences that lower patients' quality of life is low bone mineral density (BMD). By employing DXA (dual X-ray absorptiometry), BMD is evaluated. This study's objectives are to research BMD in SLE children and to describe the predicting factors. Methods: A case control study included 30 SLE patients (the SLE group) (mean age, 14.8± 2.5 years; females, 83.3%) and 30 age and sex-matched, seemingly healthy children (the Control group). They had a thorough medical history and clinical examination, as well as laboratory tests, 25(OH) vitamin D levels, and BMD evaluation by DXA scan (scores at L2-L4). The information was presented as mean and standard deviation. The Pearson's correlation and the student t-test were used for statistical analysis. At a p value of 0.05, differences were deemed statistically significant. Results: Low BMD was detected in the SLE group in comparison to the controls (p<0.001). Reduced BMD was detected in 46.6% of patients. Vitamin D level is lower in SLE group with statistically significant difference. On regression analysis; duration of disease, steroid use, and alkaline phosphatase were found to be independent variables that affected BMD. Conclusion: SLE patients frequently have low BMD. A longer course of the illness, and higher overall glucocorticoid dose were powerful predictors of low BMD. The patients may be protected from the possibility of decreased BMD by DXA monitoring and the implementation of an appropriate therapy plan.
   
     
 
       

Author Related Publications

  • Mona Mohamed Mohamed Ali El Sharkawy, "Hepatitis B Immunization Status in Children with Chronic Kidney Disease: Experience at a Single Center, Egypt", MDPI, 2023 More
  • Mona Mohamed Mohamed Ali El Sharkawy, "Evaluation of Urinary Monocyte Chemotactic Protein 1 as a Predictive Marker of Steroid Responsiveness in Children with Idiopathic Nephrotic Syndrome", كلية الطب البشرى حامعة الزقازيق, 2024 More
  • Mona Mohamed Mohamed Ali El Sharkawy, "Visfatin Levels and Cardiovascular Parameters among Children and Adolescents with Type 1 Diabetes Mellitus", كلية الطب البشرى جامعه الزقازيق, 2024 More
  • Mona Mohamed Mohamed Ali El Sharkawy, "Assessment of hepatic fibrosis in hemodialysis children and adolescents by fibroscan and hyaluronic acid", كلية الطب البشرى جامعه الزقازيق, 2023 More
  • Mona Mohamed Mohamed Ali El Sharkawy, "Assessment of Pubertal Status in Children and Adolescents with End-Stage Renal Disease on Hemodialysis", كلية الطب جامعه عين شمس, 2023 More

Department Related Publications

  • Nihad Ahmed Karam AbdelFattah, "Impact of iron deficiency anemia on the function of the immune system in children", Medicine®, 2016 More
  • Rabab Mohamed Abdelhamid Elbehidy, "MicroRNA-21 as a novel biomarker in diagnosis and response to therapy in asthmatic children.", MicroRNA-21 as a novel biomarker in diagnosis and response to therapy in asthmatic children., 2016 More
  • Doaa Youssef Mohamed, "MicroRNA-21 as a novel biomarker in diagnosis and response to therapy in asthmatic children.", MicroRNA-21 as a novel biomarker in diagnosis and response to therapy in asthmatic children., 2016 More
  • Najwa Elsayed Abdul Ghaffar Aqeel, "MicroRNA-21 as a novel biomarker in diagnosis and response to therapy in asthmatic children.", MicroRNA-21 as a novel biomarker in diagnosis and response to therapy in asthmatic children., 2016 More
  • Laila Metwally Ibrahim Sharif, "MicroRNA-21 as a novel biomarker in diagnosis and response to therapy in asthmatic children.", MicroRNA-21 as a novel biomarker in diagnosis and response to therapy in asthmatic children., 2016 More
Tweet