This research aimes to recognize the effectiveness of Acceptance and Commitment Therapy in modifying Thought Control Strategies and reducing Obsessive Compulsive disorder in post graduate students, to achieve this goal, the research was conducted on an experimental group of (6) post graduate students in Zagazig university with high degree of both thought control strategies and Obsessive compulsive thoughts scale, (4 females-2 males), aged between (24-37)years,Mean=28year, sd=5,02year ).They completed Thought Control Strategies questionnaire (TCQ) (Wells, & Davies, 1994, translated by researcher) and obsessive compulsive thoughts Scale (by: Mohammed Ahmed Saafan& Fatma El-zahraa Mohamed zaher). Results showed that there is statistically significant differences at the level of (0.05) between the mean ranks of the pre-test and post-test for the experimental group members on both TCQ and obsessive compulsive thoughts Scale in favor of the post-test measures,While there is no statistically significant differences between the mean ranks of the post-test and follow-up-test for the experimental group members on the Thought Control Strategies questionnaire, and obsessive compulsive thoughts Scale. Results show that Acceptance and Commitment Therapy is effective on modifying Thought Control Strategies and reducing Obsessive Compulsive Thoughts in post graduate students. Key words: Acceptance and Commitment Therapy, Thought Control Strategies, Obsessive Compulsive disorder. Post graduate students.