This study aimed at measuring the effect of Organizational Immunity Systems (OIS) on the relationship between Organizational Gossip (OG) and Employees’ Adaptive Performance (AP). Three Hypotheses were developed; required data were collected through a questionnaire that was provided to 344 employees working in Pharmaceutical companies in 10th of Ramadan city. Simple regression analysis has been employed to explore the relationship between organizational gossip and employees’ adaptive performance. Structure Equation Model – throught SmartPLS (v.3) programme - has been used to determine how homogenous the relationships between organizational gossip and employees’ adaptive performance for each of the demographic group (i.e. gender, age, and experience), and determining the relationships among ALL the research's variables. Results demonstrated that there is no relationship between organizational gossip and employees’ adaptive performance. Moreover, OIS plays a moderating role in this relationship; finally there are significant differences among some of the demographic groups concerning the relationship between organizational gossip and employees’ adaptive performance. Results have been discussed, scientific and practical implications have been extracted. Based on limitations, several future researches have been suggested.