Azo naringenin-based copper (II) complex as DNA binder: Synthesis, spectroscopic characterization, and diverse biological potentials

Faculty Science Year: 2024
Type of Publication: ZU Hosted Pages: 1-15
Authors:
Ahmed Mohamed Fathy Abedulrahman
Journal: Applied Organometallic Chemistry John Wiley & Sons Volume: 6
Keywords : , naringenin-based copper (II) complex , , binder: Synthesis,    
Abstract:
A new copper (II) complex containing the mono basic ligand (HL) azo naringenin was synthesized and structurally characterized by analytical, magnetic, and various spectroscopic techniques. An octahedron geometry was proposed for the assigned molecular formula [Cu(L)(CH3COO)(OH2)2]. Processing of powder X-ray diffraction data for the copper (II) complex in question by the Expo 2014 computer program confirmed the proposed structure inferred from the spectroscopic studies. The DNA binding ability of the free ligand and its copper (II) complex was tested, and the results obtained demonstrated the stronger DNA binding ability of the copper (II) complex over the azo naringenin ligand. The antioxidant potency of copper (II) complex was investigated via the DPPH free radical-scavenging assay. The present azo naringenin ligand and its copper (II) complex have shown diverse biological potentials including antitumor, antifungal, and antibacterial activities.
    
     
 
       

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