Covid-19 Pandemic-Related Stress and Coping Strategies among Adults with Chronic Diseases Attending Zagazig University Hospitals Eman Elshahat Elsayed Orabi, MD1; Hussein Mohammad Salama, MD 2; Walaa sabry Fouad, MD 3 1 Community Medicine and Public Health Department, Faculty of Medicine, Zagazig University, Sharqia Governorate, Egypt 2 Internal Medicine Department, Faculty of Medicine, Zagazig University, Sharqia Governorate, Egypt 3 Family Medicine Department, Faculty of Medicine, Zagazig University, Sharqia Governorate, Egypt2 Background: The pandemic of COVID-19 caused a major threat to the physical and mental health of all people especially those with chronic disease. To lessen the effects of the epidemic on mental health, it is crucial to study how people with chronic diseases perceive stress and their coping mechanisms. Objective: To determine COVID-19-related stress and coping strategies among adult patients with chronic disease attending Zagazig University Hospitals. Method: 317 adult patients with chronic diseases who were receiving care at Zagazig University Hospitals participated in a cross-sectional study. Patients and Methods:The study tool included a pre-constructed standardized questionnaire composed of socio demographic data, Perceived Stress Scale and Brief Coping Orientation to Problems Experienced (COPE) Inventory scale questionnaire. Results: 55.2% participants were moderately stressed, 36% were severely stressed, and 8.8% had low stress level. Infection of close one by COVID-19, concerns about own health and health of family and adapting acceptance coping strategies were statistically significant positive predictors of the COVID-19-related stress level with odds ratios (OR, 43.271, 11.0 and 18.287, respectively). While income, having chronic GIT diseases and death of close one by COVID-19 diseases were statistically significant negative predictors of the COVID-19-related stress levels (OR =0.019, 0.003, 0.392, respectively) among adults with chronic Diseases. Conclusion: Most of the participants had moderate to severe perceived stress. The most used coping strategy was religion. COVID-19 infection in close one, concerns about own and family health, adapting acceptance coping strategies, income, having chronic GIT diseases and COVID-19-related death in close one were significant predictors of the COVID-19- related stress level