Introduction: Death in cervical cancer patients is usually due to invasion and metastasis due to the aggressive nature of the tumour. Therefore, it is critical to identify potent therapeutic targets and prognostic markers to de- tect high-risk patients. Material and methods: We assessed the immunohistochemical expression of protein disulphide isomerase A3 (PDIA3) and phosphorylated signal transducer and activator of transcrip- tion 3 (p-STAT3) in 50 cases of cervical carcinoma, and we investigated their association with clinicopathological characteristics. Results: High PDIA3 was detected in 50% of cases, and statistical anal- ysis revealed a positive correlation between high PDAI3 expression and tumour grade (p < 0.001) and large tu- mour size (p = 0.010), depth of stromal invasion (p = 0.017), lymph-vascular invasion (p = 0.005), parametrial in- vasion (p < 0.001), nodal metastasis (p < 0.001), and higher International Federation of Gynaecology and Ob- stetrics stages (p < 0.001). Positive nuclear expression of p-STAT3 was detected in 44% of cases and showed significant association with histolog- ical grade (p = 0.036), tumour stage (p = 0.021), nodal metastasis (p = 0.020), and parametrial inva- sion (p = 0.045); statistical analysis of the patient’s survival data revealed that shorter overall survival and dis- ease-free survival, S, were associated with high PDIA3 expression and posi- tive p-STAT3 immunoexpression. Conclusions: The high expression of PDIA3 and p-STAT3 was related to highly aggressive cervical carcinoma with poor prognosis, and high risk of recurrence after the standardised protocol of treatment. Hence, both PDIA3 and p-STAT3 could be consid- ered as novel biomarkers for tumour progression and promising targets in the management of cervical carcinoma patients.