In this paper, a novel compact high-gain multi-layer dielectric resonator antenna for ultra- wideband applications is designed and fabricated. The proposed antenna employs a new technique to make a notch-band for the frequencies within UWB. This technique helps avoid any interference for bands like WLAN and X-band for satellite applications. In this design, several notch bands can get at different frequencies by changing the length of slots. The operating bandwidth of this antenna is between 4.8 GHz and 11.31 GHz with −10 dB return loss and maximum gain of 6 dBi. Finally, the proposed antenna is fabricated and measured to validate the simulation results. The simulation results are obtained by two different simulators; CST Studio suiteTM 2020 and HFSS 15 to ensure the validity of the design results before fabrication. The fabricated antenna is measured using Agilent R&S Z67 VNA. There is a good agreement between the simulation and experimental results.