The research aims to design and implement a proposed program for Pilates exercises and identify its effect on some physical variables and non-organic lower back pain for women and the hormone beta-endorphin, the general psychological state of women, the relationship between improving lower back pain and the general psychological state and the hormone beta-endorphin in women. The researchers used the experimental method for its suitability to the nature of the study. The research community consists of women aged (40-50) years who suffer from non-organic lower back pain. The data collection tools consisted of the General Psychological State Scale (prepared by Kamman & Flett, translated and Arabized by Adel Abdullah Muhammad), a test to measure the level of concentration of the hormone beta-endorphin, tests to measure the physical variables under study. The most important results indicated that the proposed Pilates exercise program has a positive effect on improving physical variables, non-organic lower back pain and the hormone beta-endorphin for women, and it also affected improving the general psychological state of women.