Background: Post-COVID-19 syndrome represents a wide range of ongoing symptoms that persist beyond weeks or even months, after recovery from the acute phase. Postural orthostatic tachycardia (POT) is one of these symptoms with a poorly recognized underlying pathophysiology. Purpose: We aimed to investigate atrial electromechanical delay (AEMD), demonstrated by electrocardiographic P wave dispersion (PWD) and tissue Doppler echocardiography (TDE) in patients with POSTCOVID- 19 POT (PCPOT). Methods: 94 post-COVID-19 patients were enrolled and classified into two groups; PCPOT group, 34 (36.1%) patients, and normal heart rate (NR group), 60 (63.9%) patients. 31.9% of them were males and 68.1% were females, with a mean age of 35 ± 9 years. Both groups were compared in terms of PWD and AEMD. Results: As compared to the NR group, the PCPOT group showed a significant increase in PWD (49 ± 6 versus 25.6 ± 7.8, p < 0.001), higher CRP (37 ± 9 versus 30 ± 6, p ¼ 0.04), prolonged left-atrial EMD, rightatrial EMD and inter-atrial EMD at (p ¼ 0.006, 0.001, 0.002 respectively). Multivariate logistic regression analysis revealed that P wave dispersion (b 0.505, CI (0.224e1.138), p ¼ 0.023), PA lateral (b 0.357, CI (0.214e0.697), p ¼ 0.005), PA septal (b 0.651, CI. (0.325e0.861), p ¼ 0.021), and intra-left atrial EMD (b 0.535, CI (0.353e1.346) p < 0.012) were independent predictors of PCPOT. Conclusion: Atrial heterogenicity in the form of prolonged AEMD and PWD seems to be a reasonable underlying pathophysiology of PCPOT. This could provide a new concern during the management and novel pharmacological approaches in these patients. © 2023 Cardiological Society of India. Published by Elsevier, a division of RELX India, Pvt. Ltd. This is an open access article under the CC BY-NC-ND license