Background: Osteoporosis is a metabolic bone disorder with a tendency for fracture and diabetes mellitus (DM) has a close relation to osteoporosis. Objective: Is to study the role of diabetes mellitus (DM) and diabetic nephropathy in the acceleration and production of osteoporosis. Patient and Methods: This study included 88 cases which were divided into 2 groups; 44 patients with DM and 44 patients as a control group with no sex predilection. Both groups were exposed to full history taking, bone mineral density (BMD) measurement, fasting blood sugar, urinary albumin, postprandial blood sugar, HA1C, creatinine, urea, HOMA- IR. Result: There is a strong and positive correlation between DM, diabetic nephropathy, and incidence of osteoporosis as BMD was -0.59 (-5.0:1.0) and -0.08 (-3.0:1) for cases and control respectively and 36.4% of diabetic cases had osteoporosis and only 11.4% of control had osteoporosis. Conclusions: Osteoporosis (OP) is a more complication in patients with DM. Increased risk of OP present in older age group, and female sex. Diabetic patients on long-term insulin therapy are at high risk of OP. due to high bone turnover and low bone formation.