Protective Effect of Topiramate against Diabetic Retinopathy and Computational Approach Recognizing the Role of NLRP3/IL-1/TNF- Signaling

Faculty Medicine Year: 2023
Type of Publication: ZU Hosted Pages:
Authors:
Sahar Kamal Younis Aly
Journal: Biomedicne MDPI Volume:
Keywords : Protective Effect , Topiramate against Diabetic Retinopathy    
Abstract:
The possible impact of topiramate against diabetic retinopathy (DREN) and its molecular mechanisms in relation to the nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome has not been studied before. Thus, in the present study, we aimed to utilize a computational approach to investigate the possible protective effect of topiramate on experimental DREN and explore its impact on NLRP3/interlukin-1_ signaling and brain-derived neurotrophic factor (BDNF) expression.
    
     
 
       

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