Background: Yeast vaginal infections, commonly known as vaginal candidiasis or yeast vaginitis, are a prevalent issue for women. Itching and irritation of the vulva and the area around the vaginal opening are the most typical symptoms. Although vaginal yeast infections typically manifest as sporadic episodes, they can reoccur regularly and result in long-lasting, chronic symptoms. Aim of the study was to investigate the effectiveness of sodium bicarbonate as a new promising home strategy for the treatment of vaginal yeast Infection. Subjects and Methods: Research design: A quasi-experimental design was conducted. Setting: The study was conducted at two Egyptian Maternal and Child Health Centers (MCH). Subjects: One hundered-tweleve women were recruited for this study. Tools of data collection: Four tools were used (1) Arabic structured interviewing questionnaire sheet ,(2) Women's knowledge regarding vaginal yeast infection,(3) Clinical manifestation of vaginal yeast infection record, and(4) Evaluation of the effect of sodium bicarbonate among women suffering from vaginal yeast infection. Results: the study results revealed that 68.8% of the studied women belonged to the age group of 31 to 40 years. The results of the post intervention phase showed a highly significant difference (p=0.0001) in comparison to the pre intervention phase in terms of knowledge level and symptoms related to the vaginal yeast infection of the sample under analysis. Conclusions: After using baking soda, all symptom of vaginal yeast infection has been subsided. Furthermore, the majority of the studied women became knowledgeable about vaginal infection after implementation of the intervention. Recommendations: the effectiveness and efficiency of sodium bicarbonate for treating vaginal infections require more research.