The current work aimed to study the effect of some new technological fertilizers in combination with mineral nitrogen fertilizer levels on wheat yield (Var. Msr1) and grain quality in clayey soil. Two field experiments were conducted in a Private Farm, Qutaiyifet El-Aziziya Village, Minya Elqamh District, Sharkia Governorate, Egypt, during the two successive winter seasons of 2021/2022 and 2022/2023. Split plot arrangements replicated three times, within randomized complete block design. The main plots allotted to liquid compound fertilizer (1L fed-1), commercial bio-fertilizers (at the rate of 1 kg fed-1 from Cerialine, Phosphourine and Potassiummag) and N, P, K Nano-fertilizer (400-ppm fed-1). While sub plots assigned to five mineral N- fertilizer rates (0.0, 40, 60, 80 and 100 kg fed-1) as Ammonium nitrate. The results revealed that application of liquid compound fertilizer led to a significant increase in grain yield, number of spikes / m2, straw yield, nitrogen use efficiency, N-uptake of grains and carbohydrates and protein (%) in grains compared to bio and nano fertilizers treatments. Wheat grain yield, number of spikes / m2, straw yield, as well as protein (%) and carbohydrates (%) in grains showed gradual significant increases with raising mineral nitrogen fertilizer rate from zero up to 100 kg N fed-1. On the other hand, nitrogen use efficiency decreased significantly with increasing N-fertilizer rate up to 100 kg fed-1. Regarding the interaction effect between studied factors, the treatment of liquid compound fertilizer and 100 kg N fed-1 was recorded the highest values of most studied characters.