Background: Chronic kidney disease describes loss of kidney function gradually; it may not become apparent in early stages until chronic kidney disease reaches an advanced stage that lead to accumulation of fluid, electrolytes and wastes and development of anemia Aim of study: The aim of this study was to investigate the possible role of fetuin A in improving anemia resulting from adenine induced chronic kidney disease in male rat. methods: Group A: rats feed normal diet for 21 days. Group B: rats feed normal diet with adenine for 21 days. Group C: rats feed normal diet with adenine for 21 days after that intraperitoneal administration of fetuin A every other day for 2 weeks. Serum samples were assayed for: creatinine, urea, iron ,total iron binding capacity, ferritin, tumor necrosis factor, hepcidin. Hemoglobin content, blood indices were determined, and estimated Glomerular filtration rate was measured in addition, histopathology of the kidney was done. Results: In group B: there was significant increase in serum creatinine, urea and ferritin, decrease in serum iron, total iron binding capacity, hemoglobin content and estimated Glomerular filtration rate and no significant change in blood indices . Regarding inflammatory markers significant increase. Regarding renal histopathology there was moderate tubular necrosis, tubular dilatation, and mononuclear leucocytes infiltration. In group C we observed that fetuin A ameliorated these changes. Conclusion: Fetuin A improve anemia in chronic renal failure in rat model, may be due to reduction of hepcidin or it is anti-inflammatory and anti fibrotic effect