Several new laminated glass (LG) polymer interlayer materials are now available in the market such as Ethylene-Vinyl Acetate (EVA), and SentryGlas (SG). In this paper, quasi-static testing was conducted using a full-scale static water chamber to investigate the influence of interlayer type and thickness on the extreme static response of the LG panels. However, due to the high danger and cost of explosion tests, numerical modeling was used to study the effect of these parameters on the dynamic response of the LG systems. The dynamic numerical model was verified using previously published experimental data. Results demonstrate varying pressure resistance capabilities with changes in interlayer type. EVA interlayer panels exhibit the highest deformation in dynamic behavior, while SG interlayer panels demonstrate the least deformation. Consequently, LG panels with SG interlayers exhibit the highest strength among the three types. Furthermore, the resistance of LG panels improves in the pre-cracked stage by increasing interlayer thickness.