Background The prevalence rate of breast carcinoma (BC) among multiple ethnic populations required more explanations to understand the pathogenesis mechanisms for the development of this type of cancer. The principal purpose of this work is to validate the correlation of the CCND1 (c.723G>A; rs9344) variant with an increased risk of breast carcinoma. Methods This retrospective case-controlled study was designed appertaining to 200 women including 100 BC patients and 100 unrelated cancer-free controls. The amplifcation of genomic DNA was genotyped utilizing the PCR-RFLP technique. Results The frequencies of the CCND1 (c.723G>A; rs9344) variant revealed a signifcant association with increased risk of breast carcinoma under diferent genetic models including allelic (OR=2.84, P-value<0.001), recessive (OR=4.83, P-value<0.001), and dominant (OR=3.19, P-value<0.001) models. Conclusions Our fndings concluded that the genetic biomarker of the CCND1 (c.723G>A; rs9344) variant is correlated with an elevated risk of breast carcinoma among Egyptian women