Study of Urinary Angiotensinogen as an Indicator of Severity of Diabetic Nephropathy in Type 2 Diabetes

Faculty Medicine Year: 2024
Type of Publication: ZU Hosted Pages: 162-171
Authors:
Journal: Zagazig University Medical Journal Zagazig University, Faculty of Medicine Volume: 30
Keywords : Study , Urinary Angiotensinogen , , Indicator , Severity , Diabetic    
Abstract:
Background Urinary angiotensinogen levels are higher in type 2 diabetes patients with nephropathy, a risk factor for developing renal and cardiovascular consequences. However, the potential relationship between serum urine angiotensinogen levels and albuminuria (in terms of its varying concentrations) is not yet established. As a result, we conduct this research. Method Sixty-six adults with type 2 diabetes were split into three groups, each of which included 22 people based on their degree of albuminuria, in addition to an age- and gender-matched control group of 22 healthy volunteers. Routine laboratory tests and urine angiotensinogen were evaluated in the study groups and correlated to other study parameters. Results The current study showed that urine angiotensinogen levels are more significant in diabetic patients with higher albuminuria levels, and it was also found to be associated with urinary albumin excretion in diabetic patients with different grades of albuminuria (n = 66, r = 0.666, p<0.001), and it had highly significant validity in the prediction of albuminuria among individuals with diabetes with sensitivity of 88.6%, specificity of 81.8% and accuracy of 86.4%. Conclusions According to the findings of this study, increased urine angiotensinogen levels were associated with urinary albumin excretion, and elevated urinary angiotensinogen might be utilized as an effective marker for identifying the degree of albuminuria in diabetic individuals.
   
     
 
       

Author Related Publications

  • Ahmed Abdelsabour Mohamed Moussa, "piRNA-823 Is a Unique Potential Diagnostic Non-Invasive Biomarker in Colorectal Cancer Patients", MDPI, 2021 More
  • Ahmed Abdelsabour Mohamed Moussa, "Antibiograms of intensive care units at an Egyptian tertiary care hospital", Springer Berlin Heidelberg, 2021 More
  • Ahmed Abdelsabour Mohamed Moussa, "Late onset neonatal sepsis: Can plasma gelsolin be a promising diagnostic marker?", LWW, 2024 More
  • Ahmed Abdelsabour Mohamed Moussa, "Asymptomatic Urinary Tract Infections in Patients with End Stage Renal Disease on Regular Hemodialysis", Zagazig University, Faculty of Medicine, 2024 More
  • Ahmed Abdelsabour Mohamed Moussa, "Impact of Prognostic Nutritional Index and Systemic Immune-Inflammation Index on the Clinical Outcome of Diffuse Large B Cell Lymphoma Patients Treated with RCHOP", Zagazig University, Faculty of Medicine, 2024 More

Department Related Publications

  • Amina Mohamed Talaat Mahmoud Elnagar, "7-Assessment of TNF-Related Apoptosis Inducing Ligand (TRAIL) Expression and Liver Damage in Chronic Hepatitis B Infection", لايوجد, 1900 More
  • Enas Alsayed Ahmed Soelam, "1- Significance of thyroid peroxidase and thyroglobulin antibodies and same parameters of cell mediated immunity in cases of post partum thyroid dysfunction.", لايوجد, 1900 More
  • Enas Alsayed Ahmed Soelam, "6- Siooprotein related to hypoxia ischemic encephalopathy (HIE) in neuborn infants.", لايوجد, 1900 More
  • Seham Mahrous Zaki Nassr, "New concept in histopathological grading of HCV infection at Sharkia Egypt", لايوجد, 1900 More
  • Seham Mahrous Zaki Nassr, "Non invasive markers of hepatic fibrosis in HCV pts in Sharkia Egypt", لايوجد, 1900 More
Tweet