The most frequent lymphoma in Egyptian adults is diffuse large B-cell lymphoma (DLBCL). Patients with DLBCL experience a wide variety of prognoses. It has become challenging to identify high-risk groups using IPI alone because the outcome of DLBCL patients has improved with the introduction of rituximab. It would thus be important to find prognostic indicators for the prediction of patient subgroups with poor prognosis and choose the efficient therapy regimen in accordance. One of the factors thought to contribute to the formation of cancer metastases and cancer progression is inflammation. The systemic immune inflammation index (SII) has been found to be a reliable indicator of cancer patients' prognosis. It seems that nutritional status affects how different solid tumors behave. To evaluate the immunological nutritional condition of cancer patients, the Prognostic Nutritional Index (PNI) was …