Background: Papillary thyroid carcinoma (PTC) is the most common histological type of thyroid cancer. Fortunately, most PTC patients have favorable outcomes, but about 20% of patients,have distant metastases. Therefore, the exploration of new biomarkers to know new characteristics of PTC should be updated. The aim of our study is to evaluate the possible role of Dynamin-2 and Angiopoietin-like protein 2 (Anglp2) as novel prognostic markers for papillary thyroid carcinoma. Material and Methods: In our study, we investigated the expression of DNM2 and Anglp2 in 60 cases of PTC . The clinical significance of the markers was evaluated by assessing correlation with the clinicopathological parameters. Results: High DNM2 expression PTC was significantly associated with advanced tumor stage, lymph node metastasis, recurrence and death ( p<0.002,0.018, <0.001, <0.001respectivelly).High expression levels of Anglp2 in PTC were significantly associated with advanced tumor stage, , recurrence and death (p <0.004, ,p= 0.004,p=0.003 respectively). Conclusions: DNM2 and Anglp2 were independent PTC markers indicating more likely recurrence and poor prognosis. Expression may help to select the high-risk patients for adjuvant targeted therapy.