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The IL-10 receptor inhibits cell extrinsic signals necessary for STAT1-dependent macrophage accumulation during colitis
Faculty
Veterinary Medicine
Year:
2023
Type of Publication:
ZU Hosted
Pages:
Authors:
Shrouk Elsayed Abdulaziz alsayed
Staff Zu Site
Abstract In Staff Site
Journal:
Mucosal Immunology ELSEVIER
Volume:
Keywords :
, IL-10 receptor inhibits cell extrinsic signals
Abstract:
The loss of IL-10R function leads to severe early onset colitis and, in murine models, is associated with the accumulation of immature inflammatory colonic macrophages. We have shown that IL-10R-deficient colonic macrophages exhibit increased STAT1- dependent gene expression, suggesting that IL-10R-mediated inhibition of STAT1 signaling in newly recruited colonic macrophages might interfere with the development of an inflammatory phenotype. Indeed, STAT1−/− mice exhibit defects in colonic macrophage accumulation after Helicobacter hepaticus infection and IL-10R blockade, and this was phenocopied in mice lacking IFNγR, an inducer of STAT1 activation. Radiation chimeras demonstrated that reduced accumulation of STAT1-deficient macrophages was based on a cell-intrinsic defect. Unexpectedly, mixed radiation chimeras generated with both wild-type and IL- 10R-deficient bone marrow indicated that rather than directly interfering with STAT1 function, IL-10R inhibits the generation of cell extrinsic signals that promote the accumulation of immature macrophages. These results define the essential mechanisms controlling the inflammatory macrophage accumulation in inflammatory bowel diseases.
Author Related Publications
Shrouk Elsayed Abdulaziz alsayed, "Palliative effects of Moringa olifera ethanolic extract on hematoimmunologic impacts of melamine in rats", Elsevier, 2018
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Shrouk Elsayed Abdulaziz alsayed, "Prospective Application of Nanoencapsulated Bacillus amyloliquefaciens on Broiler Chickens’ Performance and Gut Health with Efficacy against Campylobacter jejuni Colonization", MDPI, 2023
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Shrouk Elsayed Abdulaziz alsayed, "CCR2 promotes monocyte recruitment and intestinal inflammation in mice lacking the interleukin‑10 receptor", Nature Publishing Group, 2022
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Department Related Publications
Ahlaam Abd Al Aziz Gharieb Ibrahim, "Association of Plasmid-Mediated Quinolone Resistance with AmpC- Beta-Lactamase Producing E. coli strains from Different Sources", Zagazig Univerisity, 2014
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Iman Ibrahim Attia Sweilem, "The presence of toxin genes of Clostridium perfringens isolated from camels and humans in Egypt. تواجد جينات السموم في المطثية الحاطمة المعزولة من الإبل والآدميين بمصر", كلية الطب البيطرى كرواتيا, 2010
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Iman Ibrahim Attia Sweilem, "Isolation of Staphylococcus aureus from milk and human with reference to its survival on surfaces. عزل المكور العنقودى الذهبى من الحليب والآدميين مع الإشارة لبقائها على الأسطح.", كلية الطب البيطرى - جامعة الزقازيق, 2013
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Lamia Mohammad Reza Mohammad Noman, "Studies on Antibiotic Resistance of Escherichia coli isolated from poultry and children", Sues Canal Vet. Med. J, accepted for publication (2013), 2013
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Lamia Mohammad Reza Mohammad Noman, "Bacteriological studies of Salmonella typhimurium isolated from cow calves and lambs", Assiut Vet. Med. J. Vol. 60 No. 140 January 2014, 2014
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