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Mitigation of Hepatotoxicity via Boosting Antioxidants and Reducing Oxidative Stress and Inflammation in Carbendazim-Treated Rats Using Adiantum Capillus-Veneris L. Extract
Faculty
Agriculture
Year:
2023
Type of Publication:
ZU Hosted
Pages:
Authors:
Ahmed Hosieny Abdou Mhamd
Staff Zu Site
Abstract In Staff Site
Journal:
Molecules mdpi
Volume:
Keywords :
Mitigation , Hepatotoxicity , Boosting Antioxidants , Reducing Oxidative
Abstract:
Exposure to food contaminants continues to be a substantial source of human health risks all over the world, particularly in developing countries. Carbendazim (CBZ) is a chemical fungicide used to control the spread of various fungi and other pathogens in the agriculture and veterinary sectors. The hazardous effects of CBZ on human health occur due to the accumulation of its residues in agricultural food products. In this study, the possible hepatoprotective effects of Adiantum capillus-veneris L. (ACVL) extract were evaluated in CBZ-treated rats. A GC-MS analysis revealed that ACVL extract contained several bioactive hydrocarbon components and fatty acids, and that the components exerted hepatic protection by mitigating oxidative stress via upregulating antioxidant agents and neutralizing nitrogen and oxygen free radicals. Moreover, ACVL extracts relieved hepatic inflammation via decreasing NO, NF-κB, and pro-inflammatory cytokines (TNF-a, IL-6) in the liver of CBZ-treated rats, both at protein and mRNA levels. In addition, the protective effect of ACVL has appeared in the histopathological figures and function markers in the livers of CBZ-treated rats. According to the present results, ACVL extract can protect the hepatic tissue and restore its functions to a control level in CBZ-treated rats; this effect may be attributed to its antioxidant and anti-inflammatory activities.
Author Related Publications
Ahmed Hosieny Abdou Mhamd, "Genome-Wide Identification and Expression Analysis of Metal Tolerance Protein Gene Family in Medicago truncatula Under a Broad Range of Heavy Metal Stress", Frontiers, 2021
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Ahmed Hosieny Abdou Mhamd, "Nile Tilapia as bio indicator to estimate the contamination of water using SDS-PAGE and RAPA-PCR techniques", faculty of Agr. Ain Shams University, 2012
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Ahmed Hosieny Abdou Mhamd, "Estimation of heat shock protein 70 (Hsp70) gene expression in Nile tilapia (Oreochromis niloticus) using Quantitative Real-time PCR", Zagazig Journal of Agriculture Research, 2017
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Ahmed Hosieny Abdou Mhamd, "Comprehensive genome wide identification and expression analysis of MTP gene family in tomato (Solanum lycopersicum) under multiple heavy metal stress", ُELSEVIR, 2021
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Ahmed Hosieny Abdou Mhamd, "Evolution analysis of FRIZZY PANICLE ( FZP ) orthologs explored the mutations in DNA coding sequences in the grass family (Poaceae)", PeerJ, 2022
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Department Related Publications
Ahmed Mansour Mohamed Mansour Elzohery, "Genes, Genomes and Genomics", Global Science Books, Ltd, 2010
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Ahmed Mansour Mohamed Mansour Elzohery, "Bio-fertilizer and organic manure affects rice productivity in newly reclaimed saline soil.", Dynamic Soil, Dynamic Plant 2009, 2009
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Ahmed Mansour Mohamed Mansour Elzohery, "From PCR to the Bioinformatics Era and Integrative Biology The Digitalization of Life", Global Science Books, Ltd, 2009
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Ahmed Mansour Mohamed Mansour Elzohery, "Gene-Tracer: Algorithm Tracing Genes Modification from Ancestors through Offsprings", International Journal of Computer Applications (IJCA), 2012
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Ahmed Hosieny Abdou Mhamd, "Nile Tilapia as bio indicator to estimate the contamination of water using SDS-PAGE and RAPA-PCR techniques", faculty of Agr. Ain Shams University, 2012
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