Dams are built for different purposes, but failure of a dam could result in extreme disasters such as floods. The Grand Ethiopian Renaissance Dam (GERD) was mainly built for power generation, but concerns about its safety, location and site conditions have led the downstream countries to investigate the GERD’s stability. This paper aims to investigate the impact of the failure of the dam on the downstream countries using the Hydrologic Engineering Center River Analysis System (HEC-RAS). Outflow hydrographs and flood inundation maps were provided through a hypothetical dam break scenario. An unsteady flow hydrodynamic routing with a 2D model was used to simulate the failure of the dam. A sensitivity analysis study of the output’s findings against breach parameters was also performed. The breach outflow discharge increases as the breach dimension increases. However, the peak discharge decreases with increasing breach formation time. Moreover, to prepare emergency action plans, it is important to predict the inundation depth, levels, arrival of flood waves, flood coverage area and water velocity. Furthermore, the results showed that Khartoum would turn into lakes within about 10 days and flood water depth would exceed 11 m at some locations in residential areas. Moreover, the flood waves overtopped the Roseires, Sennar and Merowe dams by 11, 7 and 20 m, respectively. In addition, the level of Lake Nasser would reach 188 m above sea level and the Aswan High Dam might be in great danger.