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Susceptibility patterns and virulence genotypes of Helicobacter pylori affecting eradication therapy outcomes among Egyptian patients with gastroduodenal diseases
Faculty
Medicine
Year:
2023
Type of Publication:
ZU Hosted
Pages:
pages 2950-2960
Authors:
Ahmed Mohamed Mourad Asaad
Staff Zu Site
Abstract In Staff Site
Journal:
World Journal of Gastroenterology Baishideg Publishing Group Inc
Volume:
Volume 29(19)
Keywords :
Susceptibility patterns , virulence genotypes , Helicobacter pylori
Abstract:
BACKGROUND Helicobacter pylori (H. pylori) is a significant human pathogen that is responsible for a variety of illnesses, including mucosa-associated lymphoid tissue lymphoma, gastric cancer, peptic ulcers, and gastritis. AIM To investigate the frequency of H. pylori infection and its resistance patterns among Egyptian patients and to determine the influence of H. pylori virulence genetic determinants on the eradication success of 14-d triple therapy regimen. METHODS H. pylori infections were investigated in 72 patients with gastroduodenal complications suggestive of H. pylori infection. The cagA and vacA genotypes of cultured strains were studied using polymerase chain reaction. The patients underwent 14 d of triple-therapy treatment. The treatment response was examined using histology and a rapid urease test 6 wk after therapy discontinuation. RESULTS The intention-to-treat eradication rate was 59.2% (95%CI: 48.2%–70.3%). Rates of H. pylori resistance to clarithromycin, amoxicillin, and metronidazole were 52.8%, 81.9%, and 100%, respectively. Successful eradication of H. pylori was more significantly associated with vacA s1- positive strains [adjusted odds ratio (aOR) = 0.507, 95%CI: 0.175–0.822]. A significant association was found between failed eradication rate and H. pylori strains resistant to clarithromycin (aOR = 0.204, 95%CI: –0.005 to 0.412) and amoxicillin (aOR = 0.223, 95%CI: 0.026–0.537). CONCLUSION This study’s low H. pylori eradication rate following 14-d triple therapy is concerning and worrying. H. pylori pan-resistance to metronidazole followed by the high resistance to ciprofloxacin, amoxicillin, and clarithromycin in this research is challenging and of great concern
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Department Related Publications
Ashwak Mohamed Foad Abotaleb, "استخدام سلسله تفاعل البلمره المتسلسل مع زوج واحد من البادئات لتشخيص تفطر الدم المسبب بثلاثة انواع من الفطور في الاطفال حديثى الولادة", لايوجد, 1900
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Ayman Abdelrahman Hussinn, "الخصائص السريرية و الميكروبية لعدوى المستشفيات التى تسببها انواع البكتيريا الراكدة", لايوجد, 1900
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Hanan Mohamed Elsayed Ibrahiem, "Diagnosis of Acute Bacterial Endophthalmitis By Nested Polymerase Chain Reaction", لايوجد, 1900
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Hanan Mohamed Elsayed Ibrahiem, "Chlamydia trachomatis detection by polymerase chain reaction (PCR) in infertile women using a tubal cytobruch during laparoscopy. 1 /11/1999 Zagazig University Medical J ", لايوجد, 1900
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