Light-weight, high-strength metal matrix composites (MMCs) have been gaining prominence in various industrial applications in which the materials are exposed to static and dynamic loading conditions. Unfortunately, micron-sized MMCs frequently encounter challenges such as particle breakage and debonding at the reinforcement-matrix interface, resulting in premature failure due to the decline in their mechanical properties, making them impractical to be utilized in some crucial applications. On the other hand, metal matrix nanocomposites (MMNCs) have been proven to improve strength, ductility, and fracture toughness characteristics, which are greatly beneficial in various industrial applications such as automotive, aerospace structures, and biomaterials. This review provides a comprehensive insight into the effect of nanoparticle addition on the fatigue performance of metals and alloys. Firstly, special attention has been given to the factors influencing the fatigue life of MMNCs. Secondly, the effect of nanoparticle incorporation on the fatigue performance of common metal matrixes, including aluminum, magnesium, titanium, and steel alloys, is reviewed in detail. Finally, a summary of this review and the future aspects related to the behavior of metals with nanoparticles at cyclic loading is provided