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Sleep disorders cause Parkinson's disease or the reverse is true: Good GABA good night
Faculty
Medicine
Year:
2024
Type of Publication:
ZU Hosted
Pages:
Authors:
Mahmoud Hosny Ali Elewa Zahran
Staff Zu Site
Abstract In Staff Site
Journal:
CNS Neuroscience & Therapeutics WILEY
Volume:
Keywords :
Sleep disorders cause Parkinson's disease , , reverse
Abstract:
Background Parkinson's disease (PD) is a progressive neurodegenerative brain disease due to degeneration of dopaminergic neurons (DNs) presented with motor and non-motor symptoms. PD symptoms are developed in response to the disturbance of diverse neurotransmitters including γ-aminobutyric acid (GABA). GABA has a neuroprotective effect against PD neuropathology by protecting DNs in the substantia nigra pars compacta (SNpc). It has been shown that the degeneration of GABAergic neurons is linked with the degeneration of DNs and the progression of motor and non-motor PD symptoms. GABA neurotransmission is a necessary pathway for normal sleep patterns, thus deregulation of GABAergic neurotransmission in PD could be the potential cause of sleep disorders in PD. Aim Sleep disorders affect GABA neurotransmission leading to memory and cognitive dysfunction in PD. For example, insomnia and short sleep duration are associated with a reduction of brain GABA levels. Moreover, PD-related disorders including rigidity and nocturia influence sleep patterns leading to fragmented sleep which may also affect PD neuropathology. However, the mechanistic role of GABA in PD neuropathology regarding motor and non-motor symptoms is not fully elucidated. Therefore, this narrative review aims to clarify the mechanistic role of GABA in PD neuropathology mainly in sleep disorders, and how good GABA improves PD. In addition, this review of published articles tries to elucidate how sleep disorders such as insomnia and REM sleep behavior disorder (RBD) affect PD neuropathology and severity. The present review has many limitations including the paucity of prospective studies and most findings are taken from observational and preclinical studies. GABA involvement in the pathogenesis of PD has been recently discussed by recent studies. Therefore, future prospective studies regarding the use of GABA agonists in the management of PD are suggested to observe their distinct effects on motor and non-motor symptoms. Conclusion There is a bidirectional relationship between the pathogenesis of PD and sleep disorders which might be due to GABA deregulation.
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Mahmoud Hosny Ali Elewa Zahran, "THE EFFICACY OF ANTI-LYMPHOCYTES GLOBULINS COMPARED WITH OTHER APPROACHES IN REVERSING ACUTE GRAFT REJECTION POST LIVEDONOR RENAL TRANSPLANTATION: A 10 YEARS FOLLOW UP", European Society for Organ Transplantation, 2017
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Mahmoud Hosny Ali Elewa Zahran, "Prevalence of Pregnancy and pregnancy related complications after kidney transplantation - a retrospective study", Akshya Jewel Appartment, 2021
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Mahmoud Hosny Ali Elewa Zahran, "Correlation between Serum Magnesium and Parathyroid Hormone in Hemodialysis Patients", Faculty of Medicine, Benha University, 2020
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Mahmoud Hosny Ali Elewa Zahran, "Assessment Of Erythropoietin Efficacy And Dosing In Hemodialysis Patients", European Journal of Molecular & Clinical Medicine, 2021
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Mahmoud Hosny Ali Elewa Zahran, "Parathormone enhances eryptosis in patients with end stage renal disease treated by hemodialysis", Wiley-Blackwell, 2021
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