Construction and demolition waste (CDW), produced at various stages of construction projects, is a major problem for the construction industry. This waste has led to an international issue that is widespread and enduring. This research used a quantitative method in two stages to suggest workable options to fix this significant problem. An online survey of Egyptian construction industry professionals was conducted during the first round to gauge how three key factors affected the safe disposal of CDW (SDCDW). Management of route, collection, and transportation (MRCT), determination of illegal waste dumping sites (DIWDS), and construction waste tracking and scheduling (CWTS) are the three main factors. The development of a comprehensive framework for SDCDW, in support of Egypt's vision 2030, involved multivariate statistical analysis using the structural equation modelling (SEM) method in the second stage. The findings showed that these three factors had a favourable impact on SDCDW in Egypt. This was evidenced through mentioning the acceptable effect sizes of these three factors towards SDCDW; where MRCT showed moderate effect towards SDCDW with a value of 0.16, CWTS showed small effect towards SDCDW with a value of 0.137, and DIWDS showed small effect towards SDCDW with a value of 0.052.The study also discovered that MRCT is more effective in treating SDCDW with a model path coefficient of 0.383. However, DIWDS is the least effective when it comes to SDCDW with a model path coefficient of 0.191. In support of Egypt's Vision 2030, this paper makes concrete suggestions for the government and the construction sector regarding the safe disposal of CDW.