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Modulatory effect of thymol on the immune response and susceptibility to Aeromonas hydrophila infection in Nile tilapia fish exposed to zinc oxide nanoparticles
Faculty
Veterinary Medicine
Year:
2023
Type of Publication:
ZU Hosted
Pages:
Authors:
Samah Ramadan Elsayed Khallil
Staff Zu Site
Abstract In Staff Site
Journal:
Aquatic Toxicology Elsevier
Volume:
Keywords :
Modulatory effect , thymol , , immune response , susceptibility
Abstract:
Zinc oxide nanoparticles (ZnO-NPs) have many exciting properties that make their use in a continuous increase in various biomedical, industrial, and agricultural applications. This is associated with accumulation in the aquatic ecosystems and fish exposure with consequent deleterious effects. To determine the potential of thymol to counteract the immunotoxic effects of ZnO-NPs, Oreochromis niloticus was exposed to ZnO-NPs (⅕ LC50 =1.14 mg/L, for 28 days) with or without feeding a thymol-incorporated diet (1 or 2 g/kg diet). Our data demonstrated a reduction of aquaria water quality, leukopenia, and lymphopenia with a decrease in serum total protein, albumin, and globulin levels in exposed fish. At the same time, the stress indices (cortisol and glucose) were elevated in response to ZnO-NPs exposure. The exposed fish also revealed a decline in serum immunoglobulins, nitric oxide, and the activities of lysozyme and myeloperoxidase, in addition to reduced resistance to the Aeromonas hydrophila challenge. The RT-PCR analysis showed downregulation of antioxidant (SOD) superoxide dismutase and (CAT) catalase gene expression in the liver tissue with overexpression of the immune-related genes (TNF-α and IL-1β). Importantly, we found that thymol markedly protected against ZnO-NPs-induced immunotoxicity in fish co-supplemented with thymol (1 or 2 g/kg diet) in a dose-dependent manner. Our data confirm the immunoprotective and antibacterial effects of thymol in ZnO-NPs exposed fish, supporting the potential utility of thymol as a possible immunostimulant agent.
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Samah Ramadan Elsayed Khallil, "Differential susceptibility of kidneys and livers to proliferative processes and transcriptional level of the genes encoding desmin, vimentin, connexin 43, and nestin in rats exposed to furan", elseiver, 2018
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Samah Ramadan Elsayed Khallil, "Intermediate filament protein expression pattern and inflammatory response changes in kidneys of rats receiving doxorubicin chemotherapy and quercetin", elseiver, 2018
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Samah Ramadan Elsayed Khallil, "The Cytotoxic and Ultrastrctural Perturbations of Aluminum Exposed Nile Catfish with Special Reference to the Mitigating Effect of Vitamin C", life science journal, 2012
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Department Related Publications
Salah Meselhy Hamza , "The genotoxic effect of nerium oleander cardenoliodes extract on albino rats ", لايوجد, 1900
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Ali Heder Abdelrahman Abohaded, "Effect of the Insecticide Mephospholan (Cytrolan) on Acetylcholinestnase Activities in Egyptian Catfish. ", لايوجد, 1900
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