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Modeling the pathway of breast cancer in the Middle East
Faculty
Science
Year:
2023
Type of Publication:
ZU Hosted
Pages:
Authors:
Ahmed Nagah Saeed Majid
Staff Zu Site
Abstract In Staff Site
Journal:
Applied Mathematics and Nonlinear Sciences Sciendo
Volume:
Keywords :
Modeling , pathway , breast cancer , , Middle East
Abstract:
This paper proposed an approach for the identification of mutation mechanisms of breast cancer in women in four member countries of the Middle East Cancer Consortium ie Egypt, Jordan, Cyprus and Israel (Arabs and Jews). We set up multistage models including both gene mutation and the clonal expansion of intermediate cells. We fit the data-set related to the incidence of female breast cancer in the four member countries. Our simulation results show that the maximum number of driver mutations of breast epithelium stem cells of Egyptian women is 13, whereas there are 14 driver mutations in the genome of stem cells of female patients in Jordan, Cyprus and Israel (Arabs and Jews). In addition, the 3, 10, 5, 5 and 4 stage models are the optimal ones for the tumorigenesis of females in Egypt, Jordan, Cyprus, Israel (Arabs) and Israel (Jews), respectively. The genomic instability is caused by first three driver mutations.
Author Related Publications
Ahmed Nagah Saeed Majid, "Proton and antiproton impact excitation of H(2s) atom", Canadian Journal of Physics, 2015
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Ahmed Nagah Saeed Majid, "Optimal Control for Systems Described by Semi-linear Parabolic Equations", World Scientific and Engineering Academy and Society, 2018
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Ahmed Nagah Saeed Majid, "The effect of cigarette smoking on lung cancer evolution", Arizona State University, 2019
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Ahmed Nagah Saeed Majid, "Mathematical modeling of female breast cancer in Japan", World Scientific Publishing Co. Pte Ltd, 2020
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Ahmed Nagah Saeed Majid, "Different Mechanisms of Cigarette Smoking‑Induced Lung Cancer", Springer Netherlands, 2020
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Department Related Publications
Heba Ibrahim Mustafa, "On lower and upper intension order relations by different cover concepts", Elsevier, 2011
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Nagla Ameen Mohamed Hssan, "On the Reliability of Multi-State m-consecutive-at least-k-out-of-n: F Systems", Foundation of Computer Science (FCS), New York, USA, 2013
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Elsayed Ibrahim Abdelgalil Mahmoud, "Normal Jacobi field on Riemannian manifold", SCIK Publishing Corporation, 2013
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Alaa Hassan Attia Hassan, "Harmonic Univalent Functions with Varying Arguments Defined by Using Salagean Integral Operator", University of Alba Iulia, Romania, 2013
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Yasser AbdelAziz Amer Tolba, "blind signal separation using adaptive generalized Gamma distribution", امريكا, 2013
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