In the first part of this study, a numerical simulation model was developed using the mechanical APDL software to validate the results of the 3D-elastisity theory on the laminated sandwich plate developed by Panago. The numerical simulation model showed a good agreement to the results of Pagano’s theory in terms of deflection, normal stresses, and shear stresses. In the second part of this study, the developed numerical simulation model was used to define different plates dimensions and fibers layup orientations to examine the load response in terms of deflection and stresses. Further analysis was implemented on the natural frequencies of laminated xxx plates of the plates. The layup configurations include Unidirectional (UD), Cross-Ply (CP), Quasi-Isotropic (QI), the linear bio-inspired known as Linear-Helicoidal (LH), and the nonlinear bio-inspired known as Fibonacci-Helicoidal (FH). The following numerical simulation model can be used for the design and study of novel, sophisticated bio-inspired composite structures in a variety of configurations subjected to sinusoidal or constant loads