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Evidence-Based Complementary and Alternative Medicine
Hindawy
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Abstract: |
Te hilly and rural areas’ people of Bangladesh have a great history of putting into use numerous traditional medicinal plants to
cure diseases. Terefore, with ethanol extract of Molineria capitulata (EEMC), methanol extract of Trichosanthes tricuspidata
(METT), and methanol extract of Amorphophallus campanulatus (MEAC), we mandate evaluation of in vitro α-amylase inhibition, antioxidants, and molecular docking, and ADMET/Tanalysis. According to iodine starch methods, α-amylase inhibition
was performed, and quantitative total phenolic and favonoid content was determined by established methods, whereas DPPH free
radical scavenging and reducing power assays were performed in previously established protocols, respectively. A comparative
study among three plants (EEMC, METT, and MEAC) possessed a signifcant (p < 0.01) efect but EEMC showed the highest
impact on enzyme inhibition. Plants in the measuring phenolic content METTand favonoid measurement MEAC displayed most
potent in the same way in the DPPH test was METT, and in reducing power capability MEAC has showed the highest efect
between three extracts. Docking’s study also reveals the compounds of METT (Cyclotricuspidoside A and Cyclotricuspidoside C)
exhibit the superior score among all the compounds. Tis fnding indicates that EEMC, METT, and MEAC substantially impact
α-amylase inhibition along with antioxidants. In silico study also reveals the potency of these plants, but further in-depth, precise
molecular studies are needed.
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