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Evidence-Based Complementary and Alternative Medicine
Hidawy
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Abstract: |
Te oxadiazole ring has long been used for the treatment of several diseases. Tis study aimed to analyze the antihyperglycemic and
antioxidant roles of the 1,3,4-oxadiazole derivative with its toxicity. Diabetes was induced through intraperitoneal administration of
alloxan monohydrate at 150 mg/kg in rats. Glimepiride and acarbose were used as standards. Rats were divided into groups of normal
control, disease control, standard, and diabetic rats (treated with 5, 10, and 15 mg/kg of 1,3,4-oxadiazole derivative). After 14 days of
oral administration of 1,3,4-oxadiazole derivatives (5, 10, and 15 mg/kg) to the diabetic group, the blood glucose level, body weight,
glycated hemoglobin (HbA1c), insulin level, antioxidant efect, and histopathology of the pancreas were performed. Te toxicity was
measured by estimating liver enzyme, renal function, lipid profle, antioxidative efect, and liver and kidney histopathological study.
Te blood glucose and body weight were measured before and after treatment. Alloxan signifcantly increased blood glucose levels,
HbA1c, alanine transaminase, aspartate aminotransferase, urea, cholesterol, triglycerides, and creatinine. In contrast, body weight,
insulin level, and antioxidant factors were reduced compared to the normal control group. Treatment with oxadiazole derivatives
showed a signifcant reduction in blood glucose levels, HbA1c, alanine transaminase, aspartate aminotransferase, urea, cholesterol,
triglycerides, and creatinine as compared to the disease control group. Te 1,3,4-oxadiazole derivative signifcantly improved body
weight, insulin level, and antioxidant factors compared to the disease control group. In conclusion, the oxadiazole derivative showed
potential antidiabetic activity and indicated its potential as a therapeutic.
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