Nerve injuries have different consequences on the structure and function of their target muscles. The present research was designed to investigate effects of sciatic nerve crush on the histological structure of soleus muscle in adult male rat. The sciatic nerve was crushed at one cm proximal to its trifurcation. The histological structure of soleus muscle was examined at two, four and eight weeks after crushing the sciatic nerve. Scattered areas of muscle degeneration were observed in the sections of rat's soleus muscle at two weeks post-crush. Marked degenerative changes with loss of architecture and extensive inflammatory cell infiltration were observed at four weeks post-crush, whereas, the affected muscular areas were replaced by fibrous tissues with many blood vessels in-between. Regenerative changes and many fibroblasts were seen in the sections of soleus muscle at eight weeks after nerve crush. crushing the sciatic nerve induced degenerative changes in the soleus muscle detected at 2 weeks post-crush. The muscle fiber degeneration was more evident and more extensive at 4 weeks post-nerve crush. Evidences of regeneration with reduction of inflammatory cell infiltration were seen at eight weeks after sciatic nerve crush. It was concluded that the degenerative changes of soleus muscle progress rapidly from the second to the fourth week after sciatic nerve crush. Eight weeks after sciatic nerve crush the muscle fibers start to regenerate as a few fibroblasts are observed in the degenerated areas.