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Spectrophotometric determination of favipiravir in presence of its acid hydrolysis product
Faculty
Pharmacy
Year:
2023
Type of Publication:
ZU Hosted
Pages:
Authors:
Yasmin Ahmed Ibrahim
Staff Zu Site
Abstract In Staff Site
Journal:
BMC Chemistry Springer Nature
Volume:
129
Keywords :
Spectrophotometric determination of favipiravir , presence , , acid hydrolysis product
Abstract:
Favipiravir (FAV) has been approved as an antiviral drug used in pandemic corona virus to treat covid-19. It has an amide moiety susceptible to hydrolysis and degradation in acid medium. Therefore, four simple, sensitive, and accurate stability indicating spectrophotometric methods have been developed for the determination of FAV in presence of its acid induced degradation product. The first method describes direct determination of FAV at 323 nm. Dual wavelength method was the second developed one for FAV quantitation by recording the absorbance difference at 322.7 and 270 nm. The third method involves using first derivative peak to peak amplitude at 338.0 and 308.0 nm, while difference spectrophotometry was the fourth suggested method, and it was based on recording the spectral changes at 361.3 nm as pH changes. The obtained calibration curves were linear over 4.0–22.0 μg/mL. Accuracy of the suggested procedures ranged from 99.11 to100.06, while precision results were from 0.80 to1.68. The developed methods were used to determine FAV in pure powdered form, laboratory-prepared mixtures with their degradation product, and pharmaceutical formulation without interference from its acidic degradation product. The greenness was assessed based on GAPI and ACREE metric and was found to be compatible and in reconciliation with green analytical chemistry concepts.
Author Related Publications
Yasmin Ahmed Ibrahim, "Analytical Performance and Greenness Evaluation of Five Multi-Level Design Models Utilized for Impurity Profiling of Favipiravir, a Promising COVID-19 Antiviral Drug", MDPI, 2022
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Yasmin Ahmed Ibrahim, "Two Green Micellar HPLC and Mathematically Assisted UV Spectroscopic Methods for the Simultaneous Determination of Molnupiravir and Favipiravir as a Novel Combined COVID-19 Antiviral Regimen", MPDI, 2022
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Yasmin Ahmed Ibrahim, "CONDUCTOMETRIC TITRATION METHOD FOR DETERMINATION OF ETILEFRINE HYDROCHLORIDE, FENOTEROL HYDROBROMIDE, AND PIPAZETHATE HYDROCHLORIDE USING SILVER NITRATE", Innovare Academic Sciences, 2016
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Yasmin Ahmed Ibrahim, "Determination of pipazethate hydrochloride, fenoterol hydrobromide and clopidogrel hydrogen sulphate using citrate-capped gold nanoparticles", Journal of Chemical and Pharmaceutical Research, 2015
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Yasmin Ahmed Ibrahim, "Determination of etilefrine hydrochloride, fenoterol hydrobromide, salbutamol sulphate and estradiol valerate using surface plasmon resonance band of silver nanoparticles", Innovare Academic Sciences, 2015
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Department Related Publications
Hawaa Mohamed Khalil Salem Khalil, "Analytical Study of Protein of Milk & Milk Products ", لايوجد, 1900
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Magda Mohamed Elsayed Elhenawy, " New Methods for the Quantitative Determination of Certain Antihistaminic Drugs&Their Application in Pharmaceutical Preparations ", لايوجد, 1900
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Hisham Abdelaziz Mohamed Hashime, "The effect of the process variables on the HPLC separation of tricyclic neuroleptics on calixarene-bonded statinary phase", لايوجد, 1900
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Naglaa Abdelsatar Mohamed, "Utility of molybdophosphoric acid in qualitative and quantitative analysis of Sibutramine HCl, Sumatribtan succinate and Lomefloxacine HCl", international, 2012
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