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Coriander essential oil attenuates dexamethasone-induced acute liver injury through potentiating Nrf2/HO-1 and ameliorating apoptotic signaling
Faculty
Pharmacy
Year:
2023
Type of Publication:
ZU Hosted
Pages:
Authors:
Mona Fouad Mahmoud Abdelaziz
Staff Zu Site
Abstract In Staff Site
Journal:
Journal of Functional Foods Elsevier
Volume:
Keywords :
Coriander essential , attenuates dexamethasone-induced acute liver
Abstract:
Coriander essential oil extracted from the fruits of Coriandrum sativum is rich in linalool, γ-terpinene and α-pinene. Herein we examined the possible hepatoprotective effects of coriander essential oil on dexamethasone-induced liver injury and the possible mechanisms. Coriander essential oil at the doses of 0.5 and 1 mL/kg or metformin (50 mg/kg) was orally administered to rats for four days, one hour before dexamethasone subcutaneous injection. Liver injury was enhanced in dexamethasone-injected rats as manifested by monocyte infiltration, hepatocyte degeneration and collagen deposition besides elevated ALT and AST levels. This was accompanied by decreased Nrf2/HO-1 signaling, leading to increased lipid peroxidation and reduced glutathione depletion. Liver-antiapoptotic protein, Bcl2 was reduced, and caspase 3 expression was increased showing hepatocyte apoptosis following dexamethasone injection. Coriander essential oil dose-dependently reversed the previous changes. These findings suggest that coriander essential oil could ameliorate dexamethasone-induced liver injury via Nrf2/HO-1 and antiapoptotic signaling pathways.
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Department Related Publications
Ehsan Mahmoud Abdelaziz Abozied, "12) Chemical Constituents of Gomphocarpus Sinaicus Boiss, Family Asclepiadceae.Growing in Egypt", لايوجد, 1900
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Ehsan Mahmoud Abdelaziz Abozied, "13) Macro- and Micromorphology of the Flower and Fruit of Gomphocarpus Sinaicus Boiss. Family Asclepiadaceae. Growing in Egypt", لايوجد, 1900
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Ehsan Mahmoud Abdelaziz Abozied, "29) Improved Heigh-preformance liquid chromatographic Determination of Glycyrrhizin in Licorice and pharmaceutical preparations", لايوجد, 1900
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Samih Ibrahim Ahmed Eldhmy , "pharmacognostical Study of Some Plants Belonging to Compositae", لايوجد, 1900
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Afaf Alsayed Ali Abdelghanie, "A New Quantitative Method for Estimation of Haemolytic Saponins in Plants", لايوجد, 1900
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