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Salix babylonica L. mitigates pancreatic damage by regulating the Beclin-P62/SQSTM1 autophagy pathway in rats
Faculty
Pharmacy
Year:
2023
Type of Publication:
ZU Hosted
Pages:
Authors:
Mona Fouad Mahmoud Abdelaziz
Staff Zu Site
Abstract In Staff Site
Journal:
Journal of Ethnopharmacology Elsevier
Volume:
Keywords :
Salix babylonica , mitigates pancreatic damage , regulating
Abstract:
Ethnopharmacological relevance Salix babylonica L. belongs to the genus Salix, family Salicaceae. It is traditionally used as an antipyretic, antirheumatic, antidiabetic and for the treatment of ulcers and parasite skin diseases. It also has a range of pharmacological effects, such as anti-inflammatory, anti-tumor, antioxidant, and antibacterial effects. However, there are no reports on the phytochemical profile and efficacy of its leaves extract to modulate dexamethasone induced pancreatic damage. Aim of the study The present study was performed to annotate the phytoconstituents of Salix babylonica leaf extract and explore whether and how it could modulate dexamethasone-induced pancreatic damage and the role of oxidative stress and autophagy in mediating its protective effects. Materials and methods Wistar rats were used for this study. Salix babylonica in two dose levels (100 and 200 mg/kg) or metformin (50 mg/kg) was given by oral gavage concurrently with dexamethasone which was injected SC in a dose of 10 mg/kg for 4 consecutive days. Results LC-MS analysis furnished 84 secondary metabolites belonging to phenolic acids, salicinoids, proanthocyanidins, flavonoids, cyclohexanediol glycosides, and hydroxy fatty acids. S. babylonica at both dose levels and metformin decreased the elevated pancreatic beclin while elevated the decreased pancreatic P62/SQSTM1 content compared to dexamethasone. These effects were associated with improved histopathological changes, glycemic and lipid parameters indicating that there might be a connection between autophagy and dexamethasone-induced pancreatic damage. Given that the level of GSH was negatively correlated with the levels of beclin and positively correlated with P62/SQSTM1, while both MDA and NO levels were positively correlated with beclin and negatively correlated with P62/SQSTM1, it seems that dexamethasone induced autophagy may be attributed to dexamethasone induced pancreatic oxidative stress. Conclusion Our results indicate that S. babylonica protects pancreatic tissues against dexamethasone-induced damage by decreasing oxidative stress and its associated autophagy. Our study reveals a new mechanism for dexamethasone effects on pancreas and shows the potential therapeutic role of S. babylonica in mitigating dexamethasone adverse effects on pancreas and establishes the groundwork for future clinical applications.
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Mona Fouad Mahmoud Abdelaziz, "Anti-Inflammatory, Antipyretic, and Analgesic Properties of Potamogeton perfoliatus Extract: In Vitro and In Vivo Study", mdpi, 2021
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Mona Fouad Mahmoud Abdelaziz, "Syzygium samarangense leaf extract mitigates indomethacin-induced gastropathy via the NF-κB signaling pathway in rats", Elsevier, 2021
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Mona Fouad Mahmoud Abdelaziz, "Syzygium jambos extract mitigates pancreatic oxidative stress, inflammation and apoptosis and modulates hepatic IRS-2/AKT/GLUT4 signaling pathway in streptozotocin-induced diabetic rats", Elsevier, 2021
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Mona Fouad Mahmoud Abdelaziz, "Syzygium aqueum (Burm.f.) Alston Prevents Streptozotocin-Induced Pancreatic Beta Cells Damage via the TLR-4 Signaling Pathway", Frontiers, 2021
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Department Related Publications
Ehsan Mahmoud Abdelaziz Abozied, "12) Chemical Constituents of Gomphocarpus Sinaicus Boiss, Family Asclepiadceae.Growing in Egypt", لايوجد, 1900
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Ehsan Mahmoud Abdelaziz Abozied, "13) Macro- and Micromorphology of the Flower and Fruit of Gomphocarpus Sinaicus Boiss. Family Asclepiadaceae. Growing in Egypt", لايوجد, 1900
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Ehsan Mahmoud Abdelaziz Abozied, "29) Improved Heigh-preformance liquid chromatographic Determination of Glycyrrhizin in Licorice and pharmaceutical preparations", لايوجد, 1900
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Samih Ibrahim Ahmed Eldhmy , "pharmacognostical Study of Some Plants Belonging to Compositae", لايوجد, 1900
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Afaf Alsayed Ali Abdelghanie, "A New Quantitative Method for Estimation of Haemolytic Saponins in Plants", لايوجد, 1900
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