Cryptosporidiosis is a parasitic zoonosis implicated in severe diarrhoea in pets and humans. This study aimed to determine the prevalence and genotypes of Cryptosporidium spp. in household dogs and in-contact children, as well as the risk factors associated with children infection in Sharkia Province, Egypt. Faecal samples of 100 children (2-12 years old) and 50 dogs (3 months - one year old) were randomly collected from both rural (children: n = 85, dogs: n= 40) and urban (children: n = 15, dogs: n= 10) households. Initial parasite detection was done by light microscopy, whilst, genotyping was based on molecular diagnostic assays. The overall prevalence of Cryptosporidium spp. infection in children was 35% using microscopy and 14% using nested PCR. In dogs, it was 34% using microscopy and 24% using nested PCR. Cryptosporidium spp. from children were identified as distinct genotypes, with the predominance of human genotype I (C. hominis) over the zoonotic genotype II (C. parvum). Moreover, only zoonotic genotype II (C. parvum) was identified in dog samples. The significant risk factors associated with the prevalence of Cryptosporidium infection in children were the presence of diarrhoeal episodes during time of survey, improper disposal of garbage and dog faeces and contact with other livestock (p ≤0.05). This study concluded that the existence of C. parvum in children and dogs residing the same households confirm the zoonotic transmission and its public health significance. Also, the study recommended the necessity of hygienic disposal of dog faeces and preventing direct contact of dogs with other livestock.