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Chitosan neem nanocapsule enhances immunity and disease resistance in nile tilapia (Oreochromis niloticus)
Faculty
Veterinary Medicine
Year:
2023
Type of Publication:
ZU Hosted
Pages:
Authors:
Amany Ibrahim Ahmed alsayed
Staff Zu Site
Abstract In Staff Site
Journal:
Heliyon Elsevier
Volume:
Keywords :
Chitosan neem nanocapsule enhances immunity , disease resistance
Abstract:
Finding eco-friendly alternatives for antibiotics in treating bacterial diseases affecting the aquaculture sector is essential. Herbal plants are promising alternatives, especially when combined with nanomaterials. Neem (Azadirachta indica) leaves extract was synthesized using a chitosan nanocapsule. Chitosan neem nanocapsule (CNNC) was tested in-vitro and in-vivo against the Aeromonas sobria (A. sobria) challenge in Nile tilapia. A preliminary experiment with 120 Nile tilapia was conducted to determine the therapeutic dose of CNNC, which was established to be 1 mg/L. A treatment study was applied for seven days using 200 fish categorized into four groups (10 fish/replicate: 50 fish/group). The first (control) and second (CNNC) groups were treated with 0 and 1 mg/L CNNC in water without being challenged. The third (A. sobria) and fourth (CNNC + A. sobria) groups were treated with 0 and 1 mg/L CNNC, respectively, and challenged with A. sobria (1 × 107 CFU/mL). Interestingly, CNNC had an in-vitro antibacterial activity against A. sobria; the minimum inhibitory concentration and minimum bactericidal concentration of CNNC against A. sobria were 6.25 and 12.5 mg/mL, respectively. A. sobria challenge caused behavioral alterations, skin hemorrhage, fin rot, and reduced survivability (60%). The infected fish suffered a noticeable elevation in the malondialdehyde level and hepato-renal function markers (aspartate aminotransferase, alanine aminotransferase, and creatinine). Moreover, a clear depletion in the level of the antioxidant and immune indicators (catalase, reduced glutathione, lysozymes, nitric oxide, and complement 3) was obvious in the A. sobria group. Treatment of the A. sobria-challenged fish with 1 mg/L CNNC recovered these parameters and enhanced fish
Author Related Publications
Amany Ibrahim Ahmed alsayed, "The effects of chitosan-vitamin C nanocomposite supplementation on the growth performance, antioxidant status, immune response, and disease resistance of Nile tilapia (Oreochromis niloticus) fingerlings", elsevier, 2020
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Amany Ibrahim Ahmed alsayed, "Synthetic Salicylates and/ or Pioglitazone Ameliorative Effect in Type 2 Induced Diabetic Rats", Nexus academic publishers, 2019
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Amany Ibrahim Ahmed alsayed, "Antidiabetic Effect of Pumpkin Seeds and Gum Arabic and/or Vildagliptin on type 2 Induced Diabetes in Male Rats", unique scientific publisher, 2020
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Amany Ibrahim Ahmed alsayed, "The amelorative effect of L-arginin and omega-3 fatty acid against sodium valproate induced hepatotoxicity", academicjournals.org, 2028
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Amany Ibrahim Ahmed alsayed, "Palliative role of colloidal silver nanoparticles synthetized by moringa against Saprolegnia spp. infection in Nile Tilapia: Biochemical, immuno-antioxidant response, gene expression, and histopathological investigation", Elseiver, 2022
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Department Related Publications
Gamal Elnoby Ahmed Abdelrehem, "تأثير حمض الأسكوربك (فيتامين ج) على التسمم بالنحاس فى البلطى النيلى", لايوجد, 1900
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Rasha Mohamed Reda Mohamed Attia, "دراسة علي تأثير سلفات الزنك علي صحة اسماك البلطي النيلي.", لايوجد, 1900
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Zinab Mostafa Abdelsalam Elbohy , "الايرومونياسيس في اسماك الزينة", لايوجد, 1900
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Zinab Mostafa Abdelsalam Elbohy , "دراسات على الاصابة بالنغف الاصفر فى اسماك القراميط النيلية فى محافظة الشرقية", لايوجد, 1900
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Rasha Mohamed Reda Mohamed Attia, "In Vitro Selection of Bacteria and Isolation of Probionts from Farmed Sparus aurata with Potential for Use as Probiotics", American Institute of Science, 2015
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