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CoQ10 exerts hepatoprotective effect in fructose-induced fatty liver model in rats
Faculty
Medicine
Year:
2020
Type of Publication:
ZU Hosted
Pages:
Authors:
Ensaf Ahmed Abdelhamid
Staff Zu Site
Abstract In Staff Site
Journal:
Pharmacological Reports springer
Volume:
Keywords :
CoQ10 exerts hepatoprotective effect , fructose-induced fatty
Abstract:
Background: Excess dietary sugar is associated with deleterious metabolic effects, liver injury, and coenzyme-Q10 (CoQ10) deficiency. This study investigates the ability of CoQ10 to protect against fructose-induced hepatic damage. Methods: Rats were fed tap water or 30% fructose for 12 weeks with or without CoQ10 (10 mg/kg, po). An additional group of rats were allowed to feed on either water or 30% fructose for 12 weeks, followed by four weeks of treatment with either the vehicle or CoQ10. Results Fructose-fed rats showed lower CoQ10 levels, increased systolic pressure, increased body weight, higher liquid consumption, decreased food intake and hyperglycemia. Fructose-fed rats also showed deteriorated serum and liver lipid profiles, impaired liver function tests and oxidative status, and lower expression of adiponectin receptor 1 and 2 along with higher GLUT-2 levels. Furthermore, following fructose treatment, tyrosine kinase-PI3K pathway was inhibited. Additionally, there was an increase in the levels of apoptotic markers and serum visfatin and a decrease in the levels of adiponectin and soluble receptor of the advanced glycated end product. Consequently, several histopathological changes were detected in the liver. Concurrent or three months post-exposure administration of CoQ10 in fructose rats significantly reversed or attenuated all the measured parameters and hepato-cytoarchitecture alterations. Conclusion This study suggests CoQ10 supplement as a possible prophylaxis or treatment candidate for fructose-induced liver injury.
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Ensaf Ahmed Abdelhamid, "The Possible Protective Role of Vitamins C&E Supplemented Diet on the Testis of Adult Albino Rat with Induced–Diabetes, An Ultrastructural, Morphometrical and Biochemical Study الدور الوقائي المحتمل للغذاء المكمّٙل بخليط من فيتاميني ج و ه", Egyptian Journal of Histology, 2022
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Ensaf Ahmed Abdelhamid, "The role of lycopene Versus the normal capacity of recovery in a nanotoxicity model of the renal cortex: An ultrastructural and immunohistochemical study", Zagazig University Medical Journal, 2023
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Ensaf Ahmed Abdelhamid, "Potential Cytotoxic Effect Of Caffeinated And Non-Caffeinated Carbonated Soft Drinks On Liver And Pancreas Of Adult Male Albino Rats; (Biochemical, Histological And DNA Study)", Egyptian Society of Clinical Toxicology, 2022
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Ensaf Ahmed Abdelhamid, "Ginger ‘S Role in A Hepatic Lead Toxicity Model", Egyptian Society of Histology and Cytology, 2018
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Ensaf Ahmed Abdelhamid, "Potential role of Moringa Oleifera in alleviating paracetamol-induced nephrotoxicity in rat", the Spanish Society of Anatomy, 2020
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Department Related Publications
Ashraf Saber Bayoumi Hegab, "التاثير المحسن لفيتامين هـ ضد سمنه على التركيب النسيجى للخصيه والنمط الصبغى في الجرذان البيضاء البالغه ", لايوجد, 1900
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Gamal Mohamed Zain Elabdein, "التركيب الدقيق للخلايا المهديه والافرازية لقمع البويضات في الارانب ", لايوجد, 1900
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