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Potential Cytotoxic Effect Of Caffeinated And Non-Caffeinated Carbonated Soft Drinks On Liver And Pancreas Of Adult Male Albino Rats; (Biochemical, Histological And DNA Study)
Faculty
Medicine
Year:
2022
Type of Publication:
ZU Hosted
Pages:
Authors:
Ensaf Ahmed Abdelhamid
Staff Zu Site
Abstract In Staff Site
Journal:
Egyptian Society of Clinical Toxicology Journal Egyptian Society of Clinical Toxicology
Volume:
Keywords :
Potential Cytotoxic Effect , Caffeinated , Non-Caffeinated Carbonated
Abstract:
Objective: The carbonated soft drinks (CSDs) consumption has markedly increased worldwide in the last decades, for both the number of servings/given time and the quantity per serving. Variable health problems have been linked to CSDs consumption. This aroused suspicion about a genotoxic effect in addition to the cytotoxicity investigated. This experimental study aimed to evaluate the possible harmful effects of caffeinated versus non-caffeinated SDs on DNA and cellular integrity. Material: forty adult Wistar albino rats were allowed for free intake of two groups of CSDs (caffeinated and non-caffeinated) separately for 3months, while observing their body weights. After scarification, blood biochemistry, histopathological examination, comet analysis and morphometry were done to detect statistical significance of the findings. Results; caffeinated CSDs proved statistically to have a biochemical, genotoxic, and cytotoxic effects worse than the non-caffeinated CSDs. Conclusion: the deleterious genotoxic and cytotoxic effects of CSDs necessitates precise measures to control their free high consumption levels.
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Ensaf Ahmed Abdelhamid, "The Possible Protective Role of Vitamins C&E Supplemented Diet on the Testis of Adult Albino Rat with Induced–Diabetes, An Ultrastructural, Morphometrical and Biochemical Study الدور الوقائي المحتمل للغذاء المكمّٙل بخليط من فيتاميني ج و ه", Egyptian Journal of Histology, 2022
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Ensaf Ahmed Abdelhamid, "The role of lycopene Versus the normal capacity of recovery in a nanotoxicity model of the renal cortex: An ultrastructural and immunohistochemical study", Zagazig University Medical Journal, 2023
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Ensaf Ahmed Abdelhamid, "CoQ10 exerts hepatoprotective effect in fructose-induced fatty liver model in rats", springer, 2020
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Ensaf Ahmed Abdelhamid, "Ginger ‘S Role in A Hepatic Lead Toxicity Model", Egyptian Society of Histology and Cytology, 2018
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Ensaf Ahmed Abdelhamid, "Potential role of Moringa Oleifera in alleviating paracetamol-induced nephrotoxicity in rat", the Spanish Society of Anatomy, 2020
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Department Related Publications
Ashraf Saber Bayoumi Hegab, "التاثير المحسن لفيتامين هـ ضد سمنه على التركيب النسيجى للخصيه والنمط الصبغى في الجرذان البيضاء البالغه ", لايوجد, 1900
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